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Fetal blood levels approach maternal blood levels following parenteral administration. Withdrawal symptoms occur rein infants born to mothers World health organization receive barbiturates throughout the belastung trimester of pregnancy. (Weiher “Drug Abuse And Dependence” section.) If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should Beryllium apprised of the potential hazard to the fetus.
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Barbiturates have little analgesic action at subanesthetic doses. Rather, rein subanesthetic doses these drugs may increase the reaction to painful stimuli. All barbiturates exhibit anticonvulsant activity hinein anesthetic doses.
Hypnotic doses of these barbiturates do not appear to significantly impair uterine activity during labor. Full anesthetic doses of barbiturates decrease the force and frequency of uterine contractions. Administration of sedative-hypnotic barbiturates to the mother during labor may result rein respiratory depression rein the newborn.
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Rein primates, exposure to 3 hours of ketamine that produced a light surgical plane of anesthesia did not increase neuronal cell loss, however, treatment regimens of 5 hours or longer of isoflurane increased neuronal cell loss. Data from isoflurane-treated rodents and ketamine-treated primates suggest that the neuronal and oligodendrocyte cell losses are associated with prolonged cognitive deficits hinein learning and memory.
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Barbiturates appear to enhance the metabolism of exogenous corticosteroids probably through the induction of hepatic microsomal enzymes. Patients stabilized on corticosteroid therapy may require dosage adjustments if barbiturates are added to or withdrawn from their dosage regimen.
Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids with high concentrations rein the brain, liver, and kidneys. Lipid solubility of the barbiturates is the dominant factor hinein their Verteilung within the body.
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These studies have substantial limitations, and it is not clear if the observed effects are due to the anesthetic/sedation drug administration or other factors such as the surgery or underlying illness.